DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 4-aminobiphenyl are infrequently detected in human mammary tissue by liquid chromatography/tandem mass spectrometry.
Identifieur interne : 000510 ( France/Analysis ); précédent : 000509; suivant : 000511DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 4-aminobiphenyl are infrequently detected in human mammary tissue by liquid chromatography/tandem mass spectrometry.
Auteurs : Dan Gu ; Robert J. Turesky [États-Unis] ; Yeqing Tao ; Sophie Langouët [France] ; Gwendoline Nauwelaers [France] ; Jian-Min Yuan [États-Unis] ; Douglas Yee [États-Unis] ; Mimi C. Yu [États-Unis]Source :
- Carcinogenesis [ 0143-3334 ] ; 2012-01.
Abstract
Some epidemiological investigations have revealed that frequent consumption of well-done cooked meats and tobacco smoking are risk factors for breast cancer in women. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic aromatic amine that is formed in well-done cooked meat, and 4-aminobiphenyl (4-ABP) is an aromatic amine that arises in tobacco smoke and occurs as a contaminant in the atmosphere. Both compounds are rodent mammary carcinogens, and putative DNA adducts of PhIP and 4-ABP have been frequently detected, by immunohistochemistry (IHC) or (32)P-post-labeling methods, in mammary tissue of USA women. Because of these findings, PhIP and 4-ABP have been implicated as causal agents of human breast cancer. However, the biomarker data are controversial: both IHC and (32)P-post-labeling are non-selective screening methods and fail to provide confirmatory spectral data. Consequently, the identities of the lesions are equivocal. We employed a specific and sensitive liquid chromatography/mass spectrometry (MS) method, to screen tumor-adjacent normal mammary tissue for DNA adducts of PhIP and 4-ABP. Only 1 of 70 biopsy samples obtained from Minneapolis, Minnesota breast cancer patients contained a PhIP-DNA adduct. The level was three adducts per 10(9) nucleotides, a level that is 100-fold lower than the mean level of PhIP adducts reported by IHC or (32)P-post-labeling methods. The occurrence of 4-ABP-DNA adducts was nil in those same breast tissues. Our findings, derived from a specific mass spectrometry method, signify that PhIP and 4-ABP are not major DNA-damaging agents in mammary tissue of USA women and raise questions about the roles of these chemicals in breast cancer.
Url:
DOI: 10.1093/carcin/bgr252
Affiliations:
- France, États-Unis
- Pays de la Loire, Région Bretagne
- Angers, Rennes
- Université d'Angers, Université de Rennes 1, Université européenne de Bretagne
Links toward previous steps (curation, corpus...)
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- to stream Main, to step Exploration: 007694
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Links to Exploration step
Hal:hal-00682453Le document en format XML
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<orgName type="acronym">Irset</orgName>
<desc> <address> <addrLine>263 avenue Général Leclerc 35042 Rennes Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.irset.org</ref>
</desc>
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<tutelles><tutelle active="#struct-74911" type="direct"><org type="institution" xml:id="struct-74911" status="VALID"> <orgName>Université d'Angers</orgName>
<orgName type="acronym">UA</orgName>
<desc> <address> <addrLine>40 rue de Rennes - BP 73532 - 49035 Angers cedex 01</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-angers.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-93016" type="direct"><org type="institution" xml:id="struct-93016" status="VALID"> <orgName>Université des Antilles et de la Guyane</orgName>
<orgName type="acronym">UAG</orgName>
<desc> <address> <addrLine>Fouillole - BP 250 - 97157 Pointe-à-Pitre</addrLine>
<country key="GP"></country>
</address>
<ref type="url">http://www.univ-ag.fr/</ref>
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<tutelle active="#struct-105160" type="direct"><org type="institution" xml:id="struct-105160" status="VALID"> <orgName>Université de Rennes 1</orgName>
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<desc> <address> <addrLine>2 rue du Thabor - CS 46510 - 35065 Rennes cedex</addrLine>
<country key="FR"></country>
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<ref type="url">http://www.univ-rennes1.fr/</ref>
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<orgName type="acronym">EHESP</orgName>
<date type="start">2016-06-20</date>
<desc> <address> <addrLine>15, avenue du Pr. Léon Bernard - 35043 Rennes Cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.ehesp.fr/</ref>
</desc>
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<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
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<tutelle active="#struct-453207" type="direct"><org type="institution" xml:id="struct-453207" status="VALID"> <orgName>Structure Fédérative de Recherche en Biologie et Santé de Rennes </orgName>
<orgName type="acronym"> Biosit : Biologie - Santé - Innovation Technologique </orgName>
<desc> <address> <addrLine>Université Rennes 1 - Campus Santé Villejean - 2, avenue Professeur Léon Bernard 35043 Rennes cedex</addrLine>
<country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Angers</settlement>
<region type="region" nuts="2">Pays de la Loire</region>
</placeName>
<orgName type="university">Université d'Angers</orgName>
<placeName><settlement type="city">Rennes</settlement>
<region type="region" nuts="2">Région Bretagne</region>
</placeName>
<orgName type="university">Université de Rennes 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName>
</affiliation>
</author>
<author><name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-188179" status="INCOMING"> <orgName>Division of Cancer Control and Population Sciences</orgName>
<desc> <address> <addrLine>University of Pittsburgh Cancer Institute, and Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15232</addrLine>
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</address>
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</address>
</desc>
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</tutelle>
<tutelle active="#struct-346810" type="direct"><org type="institution" xml:id="struct-346810" status="INCOMING"><orgName>University of Pittsburgh Graduate School of Public Health</orgName>
<desc><address><country key="FR"></country>
</address>
</desc>
</org>
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</hal:affiliation>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Yee, Douglas" sort="Yee, Douglas" uniqKey="Yee D" first="Douglas" last="Yee">Douglas Yee</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-188180" status="INCOMING"> <orgName>Masonic Cancer Center</orgName>
<desc> <address> <addrLine>University of Minnesota, Minneapolis, MN 55455</addrLine>
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<desc> <address> <addrLine>3 Morrill Hall100 Church St. S.E.Minneapolis MN 55455</addrLine>
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</address>
<ref type="url">http://twin-cities.umn.edu/</ref>
</desc>
</org>
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</tutelles>
</hal:affiliation>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Yu, Mimi C" sort="Yu, Mimi C" uniqKey="Yu M" first="Mimi C." last="Yu">Mimi C. Yu</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-188180" status="INCOMING"> <orgName>Masonic Cancer Center</orgName>
<desc> <address> <addrLine>University of Minnesota, Minneapolis, MN 55455</addrLine>
<country key="US"></country>
</address>
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<tutelles><tutelle active="#struct-307094" type="direct"><org type="institution" xml:id="struct-307094" status="VALID"> <orgName>University of Minnesota [Minneapolis]</orgName>
<desc> <address> <addrLine>3 Morrill Hall100 Church St. S.E.Minneapolis MN 55455</addrLine>
<country key="US"></country>
</address>
<ref type="url">http://twin-cities.umn.edu/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>États-Unis</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1093/carcin/bgr252</idno>
<series><title level="j">Carcinogenesis</title>
<idno type="ISSN">0143-3334</idno>
<imprint><date type="datePub">2012-01</date>
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<front><div type="abstract" xml:lang="en">Some epidemiological investigations have revealed that frequent consumption of well-done cooked meats and tobacco smoking are risk factors for breast cancer in women. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic aromatic amine that is formed in well-done cooked meat, and 4-aminobiphenyl (4-ABP) is an aromatic amine that arises in tobacco smoke and occurs as a contaminant in the atmosphere. Both compounds are rodent mammary carcinogens, and putative DNA adducts of PhIP and 4-ABP have been frequently detected, by immunohistochemistry (IHC) or (32)P-post-labeling methods, in mammary tissue of USA women. Because of these findings, PhIP and 4-ABP have been implicated as causal agents of human breast cancer. However, the biomarker data are controversial: both IHC and (32)P-post-labeling are non-selective screening methods and fail to provide confirmatory spectral data. Consequently, the identities of the lesions are equivocal. We employed a specific and sensitive liquid chromatography/mass spectrometry (MS) method, to screen tumor-adjacent normal mammary tissue for DNA adducts of PhIP and 4-ABP. Only 1 of 70 biopsy samples obtained from Minneapolis, Minnesota breast cancer patients contained a PhIP-DNA adduct. The level was three adducts per 10(9) nucleotides, a level that is 100-fold lower than the mean level of PhIP adducts reported by IHC or (32)P-post-labeling methods. The occurrence of 4-ABP-DNA adducts was nil in those same breast tissues. Our findings, derived from a specific mass spectrometry method, signify that PhIP and 4-ABP are not major DNA-damaging agents in mammary tissue of USA women and raise questions about the roles of these chemicals in breast cancer.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>États-Unis</li>
</country>
<region><li>Pays de la Loire</li>
<li>Région Bretagne</li>
</region>
<settlement><li>Angers</li>
<li>Rennes</li>
</settlement>
<orgName><li>Université d'Angers</li>
<li>Université de Rennes 1</li>
<li>Université européenne de Bretagne</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Gu, Dan" sort="Gu, Dan" uniqKey="Gu D" first="Dan" last="Gu">Dan Gu</name>
<name sortKey="Tao, Yeqing" sort="Tao, Yeqing" uniqKey="Tao Y" first="Yeqing" last="Tao">Yeqing Tao</name>
</noCountry>
<country name="États-Unis"><noRegion><name sortKey="Turesky, Robert J" sort="Turesky, Robert J" uniqKey="Turesky R" first="Robert J." last="Turesky">Robert J. Turesky</name>
</noRegion>
<name sortKey="Yee, Douglas" sort="Yee, Douglas" uniqKey="Yee D" first="Douglas" last="Yee">Douglas Yee</name>
<name sortKey="Yu, Mimi C" sort="Yu, Mimi C" uniqKey="Yu M" first="Mimi C." last="Yu">Mimi C. Yu</name>
<name sortKey="Yuan, Jian Min" sort="Yuan, Jian Min" uniqKey="Yuan J" first="Jian-Min" last="Yuan">Jian-Min Yuan</name>
</country>
<country name="France"><region name="Pays de la Loire"><name sortKey="Langouet, Sophie" sort="Langouet, Sophie" uniqKey="Langouet S" first="Sophie" last="Langouët">Sophie Langouët</name>
</region>
<name sortKey="Nauwelaers, Gwendoline" sort="Nauwelaers, Gwendoline" uniqKey="Nauwelaers G" first="Gwendoline" last="Nauwelaers">Gwendoline Nauwelaers</name>
</country>
</tree>
</affiliations>
</record>
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